As with other μ-opioid agonists, tapentadol may cause spasms in the sphincter of Oddi, and it is consequently discouraged for use in patients with biliary tract illness including both of those acute and Long-term pancreatitis. People who find themselves rapid or extremely speedy metabolizers with the CYP2C9, CYP2C19, and CYP2D6 enzymes may well no